Endocrine Abstracts

Oncocytic adrenocortical neoplasm (OAN) represents a rare variant of adrenocortical carcinoma (ACC) with less than 150 cases reported in the literature. OANs account for 1.8% of adrenal masses, predominantly in adults and usually presenting as large tumors featuring hormonal secretion in 20% of cases. Accurate histological characterization of OANs is crucial as this subtype is believed to be more indolent in clinical behavior. There are 3 categories of OANs: pure oncocytic, mi...

Cushing disease is a rare endocrine disorder characterised by excess production of adrenocorticotropic hormone (ACTH) from a pituitary adenoma causing an excessive stimulation of the adrenal glands resulting in hypercortisolism. Most common clinical presentation includes a combination of signs like central obesity, facial plethora,ecchymosis, purple skin striae, hirsutism, acne, muscle weakness and atrophy. Hypertension, glucose intolerance and diabetes, hypokalaemia and osteo...

Cushing’s syndrome (CS) is a rare and complex condition. Once the diagnosis of CS is confirmed, repetitive morning ACTH measurement is indicated to assess whether CS is ACTH dependent or independent. ACTH under 2,2 pmol/l characterises ACTH-independent CS and above 4,4 pmol/l ACTH-dependent CS. Some groups recommend midnight ACTH measurement rather than the morning. The purpose of our work was to evaluate 12PM ACTH vs 8AM ACTH measurement in the etiological diagnostic of ...